Thiouracil in Thyrotoxicosis

Thiouracil in Thyrotoxicosis

Juvenile thyrotoxicosis treated with thiouracil.

Prepubertal thyrotoxicosis is a condition of some rarity and comparatively few childhood cases have so far been recorded in the literature where the drug thiouracil has been used in treatment. A review of six cases so treated was published by Williams and Janney (1947). The present case provides a suitable example both of the clinical picture and the response to treatment. Atkinson (1938) in a ...

Sternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

Enzymatic synthesis of thiouracil riboside and thiouracil desoxyriboside.

In a survey of various substrates for pyrimidine nucleoside synthesis, it was noted that inorganic orthophosphate was released when 2-thiouracil and desoxyribose-l-phosphate were incubated together with thymidine phosphorylase (1). This finding, taken as a fairly certain indication of nucleoside synthesis, has now been fully substantiated by isolation and characterization of crystalline thioura...

Thyrotoxicosis

" Scire est nescire, nisi id me Scire alius sciret SPRING, 194:1. It would not be possible to deal at all fully with the scientific aspects of this subject in an article of reasonable length, and still less would it be possible to give a resume of the enormous literature that has grown up concerning it. My purpose is much simpler ; it is to present a record of personal experience and to offer s...